Week 5 of the NFL seasoncould be a make or break week for several NFL teams.
Here are The Arizona Republic's picks for each game on theNFL Week 5 schedule, beginning with Thursday Night Football'sLos Angeles Rams vs. Seattle Seahawks game and ending with Monday Night Football's Indianapolis Colts vs. Baltimore Ravens showdown.
Click on each game for picks and predictions for that game from other sites. All times MST.
NFL Week 5 picks, predictions:
- Rams vs. Seahawks | Jets vs. Falcons | Saints vs. Washington
- Packers vs. Bengals | Patriots vs. Texans | Dolphins vs. Bucs
- Lions vs. Vikings | Broncos vs. Steelers | Eagles vs. Panthers
- Titans vs. Jaguars | Browns vs. Chargers | Bears vs. Raiders
- 49ers vs. Cardinals | Giants vs. Cowboys | Bills vs. Chiefs
- Colts vs. Ravens | NFL Week 5: Schedule/TV | Odds, lines
- The Republic's Week 5 picks/predictions | Power rankings
Thursday Night Football
Los Angeles Rams at Seattle Seahawks, 5:20 p.m., Fox, NFL Network
A Seahawks win over the Rams would pull Seattle even with Los Angeles in the division, with both chasing the Cardinals. We can see that happening in front of the 12th Man in Seattle.
Prediction: Seahawks 27, Rams 24
More:NFL power rankings: Arizona Cardinals best team after Week 4 win over Los Angeles Rams
Sunday very early game
New York Jets at Atlanta Falcons, 6:30 a.m., NFL Network
Zach Wilson tooka big step forward in the Jets' win over the Tennessee Titans in Week 4. He will take another step forward in London with a win over the Falcons.
Prediction: Jets 24, Falcons 17
Sunday early games
Detroit Lions at Minnesota Vikings, 10 a.m., Fox
The Lions don't have a win yet this season. We don't like their chances to pick up their first against an angry Vikings team at home.
Prediction: Vikings 31, Lions 21
New Orleans Saints at Washington Football Team, 10 a.m., CBS
The Saints are an enigma, looking great one game and not very good the next. Coming off a tough loss, we think Jameis Winston and company will look closer to great than bad in this one.
Prediction: Saints 24, Washington 16
New England Patriots at Houston Texans, 10 a.m., CBS
Mac Jones is getting a lot of love for his play this season. He needs to start helping his team get wins. That shouldn't be a problem against the struggling Texans.
Prediction: Patriots 28, Texans 14
Miami Dolphins at Tampa Bay Buccaneers, 10 a.m., CBS
Tom Brady and the Buccaneers didn't impress in their win against the Patriots in Week 4. They will impress in a win over the Dolphins in Week 5.
Prediction: Buccaneers 35, Dolphins 20
Green Bay Packers at Cincinnati Bengals, 10 a.m., Fox
The Bengals are one of the league's biggest surprises and have had some extra time to prepare for this one. We like the road team to escape with a win, however.
Prediction: Packers 34, Bengals 31
Denver Broncos at Pittsburgh Steelers, 10 a.m., Fox
Najee Harris has done a little bit of everything for the Steelers this season. Pittsburgh will need him to step up once again to defeat the Broncos.
Prediction: Steelers 21, Broncos 17
Philadelphia Eagles at Carolina Panthers, 10 a.m., Fox
The Panthers were knocked from the ranks of the unbeaten in Dallas, but should have a much easier time at home against the Eagles. Look for a big game from Carolina's defense on Jalen Hurts.
Prediction: Panthers 28, Eagles 20
Tennessee Titans at Jacksonville Jaguars, 10 a.m., CBS
The Titans somehow lost to the Jets in Week 4. A loss to the Jaguars in Week 5 would really be disastrous. This one could come down to the wire. Jacksonville has improved as of late.
Prediction: Titans 28, Jaguars 27
More:NFL Week 5 schedule, TV information for all 16 Week 5 NFL games
Sunday late games
Cleveland Browns at Los Angeles Chargers, 1:05 p.m., CBS
This is a really intriguing game that could feature a lot of offense. Cleveland's defense has stepped up this season and it will step up late to help the Browns edge the Chargers.
Prediction: Browns 31, Chargers 28
Chicago Bears at Las Vegas Raiders, 1:05 p.m., CBS
Can Justin Fields go to Las Vegas and lead the Bears past the Raiders? He's improving, but we're not ready to call that upset yet.
Prediction: Raiders 35, Bears 24
San Francisco 49ers at Arizona Cardinals, 1:25 p.m., Fox
We thought the Cardinals would struggle against the Rams last week. We were wrong. We don't think San Francisco will be able to stay with the Cardinals offensively in this one.
Prediction: Cardinals 38, 49ers 24
New York Giants at Dallas Cowboys, 1:25 p.m., Fox
The Cowboys appear to be the class of the NFC East early this season. They won't do anything to change that with a big win over the Giants.
Prediction: Cowboys 28, Giants 17
More:NFL Week 5 odds: Money lines, point spreads, over/under for every Week 5 NFL game
Sunday Night Football
Buffalo Bills at Kansas City Chiefs, 5:20 p.m., NBC
This one could be a preview of the AFC Championship Game. Expect a lot of scoring and a lot of fireworks in Kansas City with the home team holding on for a victory.
Prediction: Chiefs 31, Bills 27
Monday Night Football
Indianapolis Colts at Baltimore Ravens, 5:15 p.m., ESPN
The Colts got a win in Week 4, but will have to play better to beat the Ravens in Week 5. We don't see that happening.
Prediction: Ravens 28, Colts 21
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- Edge rushers|Highest paid players: Overall|By position
Reach Jeremy Cluffat jeremy.cluff@arizonarepublic.com.Follow him on Twitter @Jeremy_Cluff.
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